HuagongsheHuagongshe Chemistry Print Report · For research reference only
[(R)-1-(4-aminophenyl)pyrrolidin-3-yl]dimethylamine → 6-Bromo-3-[4-((R)-3-dimethylaminopyrrolidin-1-yl)phenyl]-3H-thieno[3,2-d]pyrimidin-4-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | [(R)-1-(4-aminophenyl)pyrrolidin-3-yl]dimethylamine | HCID 59815627 | — |
| Reactant | 5-Bromo-3-(dimethylaminomethyleneamino)thiophene-2-carboxylic acid methyl ester | HCID 60027040 | — |
| Product | 6-Bromo-3-[4-((R)-3-dimethylaminopyrrolidin-1-yl)phenyl]-3H-thieno[3,2-d]pyrimidin-4-one | HCID 68976323 | — |
Reaction Steps
5-Bromo-3-(dimethylaminomethyleneamino)thiophene-2-carboxylic acid methyl ester was reacted with [(R)-1-(4-aminophenyl)pyrrolidin-3-yl]dimethylamine by method A1. The product with the molecular weight of 418.05 (C18H19BrN4OS) was obtained in this way; MS (ESI): 419 (M+H+).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08828991B2 |
| Source dataset | uspto-grants-2014_09 |
| ORD ID | ord-b09aa307646b42ebb55e70626da66793 |
| Source note | uspto-grants-2014_09 |