Ammonia → HCID 21882700, compound

Participants

Reaction Steps

0.73 g of 4-benzyloxy-2-fluoro-3-nitropyridine (starting material M3) are dissolved in 10 ml of a 5M solution of ammonia in methanol and stirred at ambient temperature for 16 hours. The solvent is distilled off and the residue is chromatographed on silica gel (dichloromethane/petroleum ether 4:1+1% triethylamine). Concentration of the pure fractions and drying in vacuo gives 0.51 g of the title compound as a yellow solid of m.p. 145–147° C. The mass spectrum shows the molecular peak MH+ at 246.0 Da.

Provenance & Evidence