5-Cyclopropylethynyl-3-(dimethylaminomethyleneamino)thiophene-2-carboxylic acid methyl ester → HCID 57625251, compound

HRID 72207Notes

Reaction equation

HRID 72207 reaction equation
CO[C:3]([C:5]1[S:6][C:7]([C:15]#[C:16][CH:17]2[CH2:19][CH2:18]2)=[CH:8][C:9]=1[N:10]=[CH:11][N:12]([CH3:14])C)=[O:4].[CH3:20][S:21]([CH2:24][CH2:25][N:26]1[CH2:32][CH2:31][CH2:30][N:29]([C:33]2[CH:38]=[CH:37]C(N)=[CH:35][CH:34]=2)[CH2:28][CH2:27]1)(=[O:23])=[O:22]>>[CH:17]1([C:16]#[C:15][C:7]2[S:6][C:5]3[C:3](=[O:4])[N:12]([C:14]4[CH:37]=[CH:38][C:33]([N:29]5[CH2:30][CH2:31][CH2:32][N:26]([CH2:25][CH2:24][S:21]([CH3:20])(=[O:23])=[O:22])[CH2:27][CH2:28]5)=[CH:34][CH:35]=4)[CH:11]=[N:10][C:9]=3[CH:8]=2)[CH2:18][CH2:19]1

Participants

3

Reactant 2

HCID 689443485-Cyclopropylethynyl-3-(dimethylaminomethyleneamino)thiophene-2-carboxylic acid methyl esterHCID 689775964-[4-(2-Methanesulfonyl-ethyl)-[1,4]diazepan-1-yl]-phenylamine

Product 1

HCID 57625251HCID 57625251, compound

Procedure

5-Cyclopropylethynyl-3-(dimethylamino-methyleneamino)-thiophene-2-carboxylic acid methyl ester was reacted with 4-[4-(2-Methanesulfonyl-ethyl)-[1,4]diazepan-1-yl]-phenylamine by method A1. The product with the molecular weight of 496.64 (C25H28N4O3S2) was obtained in this way; MS (ESI): 497 (M+H+).

Workup

  1. customThe product with the molecular weight of 496.64 (C25H28N4O3S2) was obtained in this way

Sources & evidence

ORD record
ord-d3d230c583784a03b64f60bd7857bef5
Source dataset
uspto-grants-2014_09
Patent number
US08828991B2

Reaction notes

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