Acetic Acid → HCID 10268713, compound

Participants

Reaction Steps

To a solution of (4-Amino-5-thiophen-2-ylmethyl-pyrimidin-2-ylsulfanyl)-acetic acid ethyl ester (0.5 mmol, 155 mg) as prepared in example 12 and acetaldehyde (0.6 mmol, 27 mg) in 1.25 ml of DMF was added acetic acid (0.25 ml) and sodium cyanoborohydride (0.6 mmol, 38 mg) and the mixture was shaken for two days at r.t. The title compound, MS: m/e=338.2 (M+H+), was obtained from the mixture by HPLC chromatography (YMC CombiPrep C18 column 50×20 mm, solvent gradient 10–95% CH3CN in 0.1% TFA(aq) over 6.0 min, λ=230 nm, flow rate 40 ml/min).

Provenance & Evidence