Potassium Carbonate → 6-bromo-9-(4-bromo-3,5-dimethyl-pyridin-2-yl methyl)-9H-purin-2-ylamine

https://huagongshe.com/reaction/722087

Participants

Role	Name	HCID	Charge
Reactant	Potassium Carbonate	HCID 11430	—
Reactant	4-Bromo-2-chloromethyl-3,5-dimethylpyridine	HCID 16736351	—
Reactant	6-bromo-1H-purin-2-amine	HCID 178508265	—
Solvent	Dimethylformamide	HCID 6228	—
Product	6-bromo-9-(4-bromo-3,5-dimethyl-pyridin-2-yl methyl)-9H-purin-2-ylamine	HCID 21883011	57.4%

Reaction Conditions

Temperature	50 °C

Reaction Steps

A mixture of 6-bromo-9H-purin-2-ylamine (2.4 g, 11 mmol), 4-bromo-2-chloromethyl-3,5-dimethyl pyridine (3.5 g, 15 mmol), K2CO3 (2.07 g, 15 mmol) and DMF (50 mL) was stirred at 50° C. for 2 h. Work-up and flash chromatography gave the title compound as a white solid (2.6 g, 56%). HPLC Rt: 5.415 min. 1H-NMR (CDCl3): δ 8.17 (s, 1H), 7.88 (s, 1H), 5.38 (s, 2H), 5.05 (s, 2H), 2.51 (s, 3H), 2.37 (s, 3H).

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US07138401B2
Source dataset	uspto-grants-2006_11
ORD ID	ord-d0e91998d6a64901b97956fb345218ec
Source note	uspto-grants-2006_11