HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 722090Generated: October 30, 2026
Dimethylformamide → HCID 21882877, compound
https://huagongshe.com/reaction/722090
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Dimethylformamide | HCID 6228 | — |
| Reactant | Methyl iodide | HCID 6328 | — |
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | HCID 21882971 | HCID 21882971 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Product | HCID 21882877 | HCID 21882877 | — |
Reaction Steps
A mixture of 6-chloro-9-(5-hydroxy-4-hydroxymethyl-6-methyl-pyridin-3-ylmethyl)-9H-purin-2-ylamine, MeI, K2CO3 (excess) and DMF was heated to 50° C. for 15 min. Work-up (EtOAc), drying (MgSO4), evaporation, and purification by preparative TLC gave the title compound. HPLC Rt: 5.446 min. 1H-NMR (CDCl3) δ 8.35 (s, 1H), 7.70 (s, 1H), 5.35 (s, 2H), 5.25 (s, 2H), 5.15 (s, 2H), 3.80 (s, 3H) 2.59 (s, 3H), 1.970 (s, 3H).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US07138401B2 |
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| Source dataset | uspto-grants-2006_11 |
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| ORD ID | ord-ef6ad172085f40abb07d7590254c6b50 |
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| Source note | uspto-grants-2006_11 |
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