HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium Methoxide → (5-Chloro-6-methoxypyridin-3-yl)methanol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium Methoxide | HCID 10942334 | — |
| Reactant | (5,6-Dichloropyridin-3-yl)methanol | HCID 21882961 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | (5-Chloro-6-methoxypyridin-3-yl)methanol | HCID 14817551 | — |
Reaction Steps
(5,6-Dichloro-pyridin-3-yl)-methanol was dissolved in a saturated solution of NaOMe in MeOH and heated to reflux overnight. Evaporation of MeOH, work-up (EtOAc) and evaporation gave the title compound. 1H-NMR (CDCl3) δ 8.03 (d, 1H), 7.72 (d, 1H), 4.65 (s, 2H), 4.04 (s, 3H).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07138401B2 |
| Source dataset | uspto-grants-2006_11 |
| ORD ID | ord-dc864135706449daa346ce33a5d13f37 |
| Source note | uspto-grants-2006_11 |