HuagongsheHuagongshe Chemistry Print Report · For research reference only
Nitric Acid → HCID 21883012, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Nitric Acid | HCID 944 | — |
| Reactant | HCID 16735062 | HCID 16735062 | — |
| Reactant | Ethyl acetate hexane | HCID 21226206 | — |
| Solvent | Acetic Acid | HCID 176 | — |
| Product | HCID 21883012 | HCID 21883012 | — |
Reaction Steps
A solution of 6-chloro-9-(3,4,5-trimethoxy-benzyl)-9H-purin-2-ylamine in acetic acid was treated with fuming HNO3 at 0° C. for 15 min. Work-up and preparative TLC (EtOAc:hexane 1:1) gave N-[6-chloro-9-(3,4,5-trimethoxy-benzyl)-9H-purin-2-yl]-acetamide. HPLC Rt: 5.744 min. 1H-NMR (CDCl3): δ 8.09 (s, 1H), 6.58 (s, 2H), 5.33 (s, 2H), 3.85 (s, 3H), 3.85 (s, 6H), 2.43 (s, 3H).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07138401B2 |
| Source dataset | uspto-grants-2006_11 |
| ORD ID | ord-459a2574dff045229660b18df9171d61 |
| Source note | uspto-grants-2006_11 |