HuagongsheHuagongshe Chemistry Print Report · For research reference only
5-(2-Cyclopropylethyl)-3-(dimethylaminomethyleneamino)thiophene-2-carboxylic acid methyl ester → 6-(2-Cyclopropylethyl)-3-(4-{(R)-3-[(2-methanesulfonylethyl)methylamino]pyrrolidin-1-yl}phenyl)-3H-thieno[3,2-d]pyrimidin-4-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 5-(2-Cyclopropylethyl)-3-(dimethylaminomethyleneamino)thiophene-2-carboxylic acid methyl ester | HCID 68938687 | — |
| Reactant | [(R)-1-(4-aminophenyl)pyrrolidin-3-yl]-(2-methanesulfonylethyl)methylamine | HCID 68977203 | — |
| Product | 6-(2-Cyclopropylethyl)-3-(4-{(R)-3-[(2-methanesulfonylethyl)methylamino]pyrrolidin-1-yl}phenyl)-3H-thieno[3,2-d]pyrimidin-4-one | HCID 57625297 | — |
Reaction Steps
5-(2-Cyclopropylethyl)-3-(dimethylaminomethyleneamino)thiophene-2-carboxylic acid methyl ester was reacted with [(R)-1-(4-aminophenyl)pyrrolidin-3-yl]-(2-methanesulfonylethyl)methylamine by method A1. The product with the molecular weight of 500.57 (C25H32N4O3S2) was obtained in this way; MS (ESI): 501 (M+H+).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08828991B2 |
| Source dataset | uspto-grants-2014_09 |
| ORD ID | ord-da7c56f6377842599c8942a175a6d475 |
| Source note | uspto-grants-2014_09 |