Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Ethanethiol | HCID 6343 | — |
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | HCID 11294416 | HCID 11294416 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | HCID 21882929 | HCID 21882929 | — |
Reaction Steps
A mixture of 6-bromo-9-(2-bromo-3,4,5-trimethoxy-benzyl)-9H-purin-2-ylamine (see previous example), EtSH, K2CO3 and THF was placed in a pressure vessel and heated to 70° C. for 6 h. Work-up and purification by preparative TLC (EtOAc:hexane 1:1) gave the title compound. HPLC Rt: 6.039 min. 1H-NMR (CDCl3): δ 7.72 (s, 1H), 6.62 (s, 1H), 5.30 (s, 2H), 4.98 (s, 2H), 3.91 (s, 3H), 3.88 (s, 3H), 3.74 (s, 3H), 3.35–3.29 (q, 2H), 1.44–1.41 (t, 3H).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US07138401B2 |
|---|
| Source dataset | uspto-grants-2006_11 |
|---|
| ORD ID | ord-0583bd96c71047edbe462cd8331288c6 |
|---|
| Source note | uspto-grants-2006_11 |
|---|
