HuagongsheHuagongshe Chemistry Print Report · For research reference only
Potassium Carbonate → 6-Bromo-9-(3,4,5-trimethyl-pyridin-2-ylmethyl)-9H-purin-2-ylamine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | 2-Bromomethyl-3,4,5-trimethyl-pyridine | HCID 16735051 | — |
| Reactant | 6-bromo-1H-purin-2-amine | HCID 178508265 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 6-Bromo-9-(3,4,5-trimethyl-pyridin-2-ylmethyl)-9H-purin-2-ylamine | HCID 21883003 | — |
Reaction Steps
The compound was obtained by reacting 2-bromomethyl-3,4,5-trimethyl-pyridine (see example 117) with 6-bromo-9H-purin-2-ylamine in the presence of K2CO3 in DMF for 0.5 h at 50° C. as described in the general procedure 1.1. HPLC Rt: 4.045 min. 1H-NMR (CDCl3): δ 8.18 (s, 1H), 7.85 (s, 1H), 5.37 (s, 2H), 5.10 (s, 2H), 2.29 (s, 3H), 2.27 (s, 3H), 2.22 (s, 3H).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07138401B2 |
| Source dataset | uspto-grants-2006_11 |
| ORD ID | ord-1b1b0885a8d941f1970ae75b33c24c56 |
| Source note | uspto-grants-2006_11 |