Water → 3-[4-((R)-3-Dimethylaminopyrrolidin-1-yl)phenyl]-6-piperidin-1-yl-3H-thieno[3,2-d]pyrimidin-4-one

Participants

Role	Name	HCID	Charge
Reactant	Water	HCID 962	—
Reactant	Piperidine	HCID 8082	—
Reactant	6-Bromo-3-[4-((R)-3-dimethylaminopyrrolidin-1-yl)phenyl]-3H-thieno[3,2-d]pyrimidin-4-one	HCID 68976323	—
Solvent	Ethyl Acetate	HCID 8857	—
Product	3-[4-((R)-3-Dimethylaminopyrrolidin-1-yl)phenyl]-6-piperidin-1-yl-3H-thieno[3,2-d]pyrimidin-4-one	HCID 57625299	—

Reaction Conditions

Temperature	100 °C

Reaction Steps

A mixture of 6-bromo-3-[4-((R)-3-dimethylaminopyrrolidin-1-yl)phenyl]-3H-thieno[3,2-d]pyrimidin-4-one (40 mg) and piperidine (492 mg) was heated at 100° C. for 2 days. Water and ethyl acetate were then added, and the organic phase was washed twice with water. The ethyl acetate phase was dried over sodium sulfate and the solvent was removed in vacuo. The residue was purified by preparative HPLC. The product with the molecular weight of 423.58 (C23H29N50S) was obtained in this way; MS (ESI): 424 (M+H+).

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US08828991B2
Source dataset	uspto-grants-2014_09
ORD ID	ord-81eb96523a414840b71293a65f0edb3a
Source note	uspto-grants-2014_09