N-benzylhydroxylamine hydrochloride → N-Benzyl-9-(3-chloro-2,6-difluorobenzyl)-N-hydroxy-9H-beta-carboline-3-carboxamide

HRID 722130Notes

Reaction equation

HRID 722130 reaction equation
[Cl:1][C:2]1[C:3]([F:26])=[C:4]([C:22]([F:25])=[CH:23][CH:24]=1)[CH2:5][N:6]1[C:18]2[CH:17]=[N:16][C:15]([C:19]([OH:21])=O)=[CH:14][C:13]=2[C:12]2[C:7]1=[CH:8][CH:9]=[CH:10][CH:11]=2.Cl.[CH2:28]([NH:35][OH:36])[C:29]1[CH:34]=[CH:33][CH:32]=[CH:31][CH:30]=1>>[CH2:28]([N:35]([OH:36])[C:19]([C:15]1[N:16]=[CH:17][C:18]2[N:6]([CH2:5][C:4]3[C:22]([F:25])=[CH:23][CH:24]=[C:2]([Cl:1])[C:3]=3[F:26])[C:7]3[C:12]([C:13]=2[CH:14]=1)=[CH:11][CH:10]=[CH:9][CH:8]=3)=[O:21])[C:29]1[CH:34]=[CH:33][CH:32]=[CH:31][CH:30]=1

Participants

3

Reactant 2

HCID 11332622N-benzylhydroxylamine hydrochlorideHCID 218833949-(3-chloro-2,6-difluorobenzyl)-9H-beta-carboline-3-carboxylic acid

Product 1

HCID 10457764N-Benzyl-9-(3-chloro-2,6-difluorobenzyl)-N-hydroxy-9H-beta-carboline-3-carboxamide

Procedure

The title compound is prepared by coupling of 9-(3-chloro-2,6-difluorobenzyl)-9H-β-carboline-3-carboxylic acid and N-benzyl hydroxylamine hydrochloride under conditions similar to those provided in step (b) of example 7.

Workup

  1. customthose provided in step (b) of example 7

Sources & evidence

ORD record
ord-999147c0d13b45c394021d9a6844b13e
Source dataset
uspto-grants-2006_11
Patent number
US07138408B2

Reaction notes

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