HCID 21882791, compound → HCID 21882813, compound

Participants

Reaction Steps

To a degassed solution of the product of Example 27 (7.6 g) in methanol/EtOAc (1:1; 300 ml) was added 10% palladium on carbon (1.3 g). The mixture was hydrogenolysed at 50 psi for 4 hrs, filtered and concentrated to give the title compound as a white foam (5.5 g). 1H NMR (d6-DMSO 360 MHz) δH 0.90 (3H, t, J=7.2), 1.03 (2H, m), 1.55 (2H, m), 1.63 (2H, m), 2.24 (2H, brm), 2.40 (2H, m), 2.87 (2H, t, J=7.1), 3.04 (1H, d, J=15.6), 3.10 (1H, d, J=15.6), 3.14 (2H, s), 6.47 (2H, m), 6.84 (1H, d, J=8), 7.60 (1H, s), 9.00 (1H, s).

Provenance & Evidence