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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 72217Generated: October 25, 2026

Methyl 3-(2,2,2-trifluoroacetamido)thiophene-2-carboxylate → 5-Cyclopentanecarbonyl-3-(2,2,2-trifluoroacetylamino)thiophene-2-carboxylic acid methyl ester

https://huagongshe.com/reaction/72217

Reaction equation

Participants

RoleNameHCIDCharge
ReactantMethyl 3-(2,2,2-trifluoroacetamido)thiophene-2-carboxylateHCID 2805185—
ReactantCyclopentanecarboxylic acid methoxymethylamideHCID 45084462—
Product5-Cyclopentanecarbonyl-3-(2,2,2-trifluoroacetylamino)thiophene-2-carboxylic acid methyl esterHCID 86628785—

Reaction Steps

3-(2,2,2-Trifluoroacetylamino)thiophene-2-carboxylic acid methyl ester and cyclopentanecarboxylic acid methoxymethylamide were reacted by method M. The product with the molecular weight of 349.33 (C14H14F3NO4S) was obtained in this way; MS (ESI): 350 (M+H+).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08828991B2
Source datasetuspto-grants-2014_09
ORD IDord-679a0478d72b48cab53acb33c9e08c05
Source noteuspto-grants-2014_09