Sodium Carbonate → 2-(1-Azabicyclo[2.2.2]oct-3-yl)-N-(4'-fluoro-1,1'-biphenyl-4-yl)acetamide Hydrochloride

Participants

Reaction Steps

In accordance with the general method, 60 mg (0.17 mmol) of 2-(1-azabicyclo[2.2.2]oct-3-yl)-N-(4-bromophenyl)acetamide hydrochloride, 23.3 mg (0.17 mmol) of 4-fluorophenylboronic acid, 0.17 ml of 2M sodium carbonate solution and 6.1 mg (0.01 mmol) of bis(diphenylphosphino)ferrocenepalladium(II) chloride are reacted in 1 ml of dimethylformamide. 32 mg (51% of theory) of the title compound are obtained.

Provenance & Evidence