HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-[3-Methyl-5-(4-nitrophenyl)-4H-1,2,4-triazol-4-yl]benzoic acid → 2-[3-(4-Aminophenyl)-5-methyl-4H-1,2,4-triazol-4-yl]benzoic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-[3-Methyl-5-(4-nitrophenyl)-4H-1,2,4-triazol-4-yl]benzoic acid | HCID 21883871 | — |
| Catalyst | Palladium | HCID 23938 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | 2-[3-(4-Aminophenyl)-5-methyl-4H-1,2,4-triazol-4-yl]benzoic acid | HCID 21883891 | — |
Reaction Steps
was prepared by hydrogenating 270 mg of 2-[3-methyl-5-(4-nitrophenyl)-[1,2,4]triazol-4-yl]benzoic acid in the presence of Pd/C in tetrahydrofuran and purified by column chromatography (silica gel, solvent: 95:5 dichloromethane:methanol).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07138414B2 |
| Source dataset | uspto-grants-2006_11 |
| ORD ID | ord-b495dac1305d4104b8ac2d22b55df57e |
| Source note | uspto-grants-2006_11 |