Benzoyl isocyanate, 2-chloro-4-fluoro- → HCID 178523926, compound

HRID 722212Notes

Reaction equation

HRID 722212 reaction equation
[Cl:1][C:2]1[CH:12]=[C:11]([F:13])[CH:10]=[CH:9][C:3]=1[C:4]([N:6]=[C:7]=[O:8])=[O:5].[Cl:14][C:15]1[CH:20]=[C:19]([C:21]2[NH:25][N:24]=[N:23][N:22]=2)[CH:18]=[CH:17][C:16]=1[NH2:26]>C(#N)C>[Cl:1][C:2]1[CH:12]=[C:11]([F:13])[CH:10]=[CH:9][C:3]=1[C:4]([NH:6][C:7]([NH:26][C:16]1[CH:17]=[CH:18][C:19]([C:21]2[NH:25][N:24]=[N:23][N:22]=2)=[CH:20][C:15]=1[Cl:14])=[O:8])=[O:5]

Participants

4

Reactant 2

HCID 11521269Benzoyl isocyanate, 2-chloro-4-fluoro-HCID 178507472HCID 178507472, compound

Product 1

HCID 178523926HCID 178523926, compound

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Conditions

Temperature
40 °C

Procedure

The solution of equivalent amounts of 2-chloro-4-fluorobenzoyl isocyanate was added dropwise to the solution of 100 mg of 2-chloro-4-(1H-tetrazol-5-yl)phenylamine in 3 ml of acetonitrile and the mixture was stirred at 40° C. for 60 minutes. The solid formed was filtered off with suction and dried under reduced pressure.

Workup

  1. customThe solid formed
  2. filtrationwas filtered off with suction
  3. customdried under reduced pressure

Sources & evidence

ORD record
ord-7211b266ca5c4073acdc767b4e1e4914
Source dataset
uspto-grants-2006_11
Patent number
US07138414B2

Reaction notes

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