2-Chloro-4,5-difluorobenzoyl Isocyanate → HCID 178523927, compound

HRID 722213Notes

Reaction equation

HRID 722213 reaction equation
[Cl:1][C:2]1[CH:12]=[C:11]([F:13])[C:10]([F:14])=[CH:9][C:3]=1[C:4]([N:6]=[C:7]=[O:8])=[O:5].[Cl:15][C:16]1[CH:21]=[C:20]([C:22]2[NH:26][N:25]=[N:24][N:23]=2)[CH:19]=[CH:18][C:17]=1[NH2:27]>C(#N)C>[Cl:1][C:2]1[CH:12]=[C:11]([F:13])[C:10]([F:14])=[CH:9][C:3]=1[C:4]([NH:6][C:7]([NH:27][C:17]1[CH:18]=[CH:19][C:20]([C:22]2[NH:26][N:25]=[N:24][N:23]=2)=[CH:21][C:16]=1[Cl:15])=[O:8])=[O:5]

Participants

4

Reactant 2

HCID 115575832-Chloro-4,5-difluorobenzoyl IsocyanateHCID 178507472HCID 178507472, compound

Product 1

HCID 178523927HCID 178523927, compound

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Conditions

Temperature
40 °C

Procedure

The solution of equivalent amounts of 2-chloro-4,5-difluorobenzoyl isocyanate was added dropwise to the solution of 100 mg of 2-chloro-4-(1H-tetrazol-5-yl)phenylamine in 3 ml of acetonitrile and the mixture was stirred at 40° C. for 60 minutes. The solid formed was filtered off with suction and dried under reduced pressure.

Workup

  1. customThe solid formed
  2. filtrationwas filtered off with suction
  3. customdried under reduced pressure

Sources & evidence

ORD record
ord-2d8baf1c8f39430098b925f9ad4f4a7e
Source dataset
uspto-grants-2006_11
Patent number
US07138414B2

Reaction notes

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