Cyanogen Bromide → 5-(2-Nitrophenyl)-1,3,4-oxadiazol-2-amine

HRID 722218노트

반응식

HRID 722218 반응식
[N:1]#[C:2]Br.[N+:4]([C:7]1[CH:16]=[CH:15][CH:14]=[CH:13][C:8]=1[C:9]([NH:11][NH2:12])=[O:10])([O-:6])=[O:5]>C(#N)C>[N+:4]([C:7]1[CH:16]=[CH:15][CH:14]=[CH:13][C:8]=1[C:9]1[O:10][C:2]([NH2:1])=[N:12][N:11]=1)([O-:6])=[O:5]

참가 물질

4

반응물 2

HCID 10476Cyanogen BromideHCID 3781218o-Nitrobenzohydrazide

생성물 1

HCID 7120425-(2-Nitrophenyl)-1,3,4-oxadiazol-2-amine

시약·촉매·용매 1

HCID 6342Acetonitrile용매2회

실험 절차

4 ml of a 5M cyanogen bromide solution in acetonitrile were added dropwise to the solution of 3.6 g of 2-nitrobenzoic hydrazide in 20 ml of acetonitrile. This resulted first in a clear solution, then a solid precipitated out which was filtered off with suction after continuing to stir for a short time, washed again with acetonitrile and dried under reduced pressure.

후처리

  1. customThis resulted first in a clear solution
  2. customa solid precipitated out which
  3. filtrationwas filtered off with suction
  4. washwashed again with acetonitrile
  5. customdried under reduced pressure

출처 및 근거

ORD 기록
ord-db67281e842a443a941f216a9cc75985
출처 데이터셋
uspto-grants-2006_11
특허 번호
US07138414B2

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