4-(4-Methyl-1,4-diazepan-1-yl)aniline → 6-(4-Hydroxytetrahydropyran-4-yl)-3-[4-(4-methyl[1,4]diazepan-1-yl)phenyl]-3H-thieno[3,2-d]pyrimidin-4-one

HRID 72222Notes

Reaction equation

HRID 72222 reaction equation
CO[C:3]([C:5]1[S:6][C:7]([C:15]2([OH:21])[CH2:20][CH2:19][O:18][CH2:17][CH2:16]2)=[CH:8][C:9]=1[N:10]=[CH:11][N:12]([CH3:14])C)=[O:4].[CH3:22][N:23]1[CH2:29][CH2:28][CH2:27][N:26]([C:30]2[CH:35]=[CH:34]C(N)=[CH:32][CH:31]=2)[CH2:25][CH2:24]1>>[OH:21][C:15]1([C:7]2[S:6][C:5]3[C:3](=[O:4])[N:12]([C:14]4[CH:34]=[CH:35][C:30]([N:26]5[CH2:27][CH2:28][CH2:29][N:23]([CH3:22])[CH2:24][CH2:25]5)=[CH:31][CH:32]=4)[CH:11]=[N:10][C:9]=3[CH:8]=2)[CH2:16][CH2:17][O:18][CH2:19][CH2:20]1

Participants

3

Reactant 2

HCID 130079514-(4-Methyl-1,4-diazepan-1-yl)anilineHCID 689402743-(Dimethylaminomethyleneamino)-5-(4-hydroxytetrahydropyran-4-yl)thiophene-2-carboxylic acid methyl ester

Product 1

HCID 248597046-(4-Hydroxytetrahydropyran-4-yl)-3-[4-(4-methyl[1,4]diazepan-1-yl)phenyl]-3H-thieno[3,2-d]pyrimidin-4-one

Procedure

3-(Dimethylaminomethyleneamino)-5-(4-hydroxytetrahydropyran-4-yl)thiophene-2-carboxylic acid methyl ester and 4-(4-methyl[1,4]diazepan-1-yl)phenylamine were reacted by method A1. The product with the molecular weight of 440.57 (C23H28N4O3S) was obtained in this way; MS (EST): 441 (M+H+).

Workup

  1. customThe product with the molecular weight of 440.57 (C23H28N4O3S) was obtained in this way

Sources & evidence

ORD record
ord-2b8c3e8ecc1e4d21a2d0b7b4679ca00b
Source dataset
uspto-grants-2014_09
Patent number
US08828991B2

Reaction notes

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