HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 722221Generated: October 29, 2026
Pyridine → N-[4-(5-oxo-4,5-dihydro-[1,2,4]oxadiazol-3-yl)-2-trifluoromethoxyphenyl]acetamide
https://huagongshe.com/reaction/722221
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Pyridine | HCID 1049 | — |
| Reactant | Ethyl chloroformate | HCID 10928 | — |
| Reactant | N-methyl-2-pyrrolidone | HCID 13387 | — |
| Reactant | N-[4-[(E)-N'-hydroxycarbamimidoyl]-2-(trifluoromethoxy)phenyl]acetamide | HCID 178474202 | — |
| Solvent | Water | HCID 962 | — |
| Product | N-[4-(5-oxo-4,5-dihydro-[1,2,4]oxadiazol-3-yl)-2-trifluoromethoxyphenyl]acetamide | HCID 135839374 | — |
Reaction Steps
The mixture consisting of 130 mg of N-[4-(N-hydroxycarbamimidoyl)-2-trifluoromethoxyphenyl]acetamide, 2 ml of N-methylpyrrolidone, 0.55 ml of pyridine and 0.049 ml of ethyl chloroformate was stirred at 80° C. for 5 hours. After cooling, the mixture was diluted with water and the product was extracted with 20 ml of ethyl acetate. The organic phase was dried over sodium sulfate and evaporated at 40° C. under reduced pressure.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US07138414B2 |
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| Source dataset | uspto-grants-2006_11 |
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| ORD ID | ord-8bacab7f953c47d2bcdb12309272f8b9 |
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| Source note | uspto-grants-2006_11 |
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