Benzoyl isocyanate, 2-chloro-4-fluoro- → 1-(2-Chloro-4-fluorobenzoyl)-3-[2-methyl-4-(3-methyl-5-oxo-2,5-dihydropyrazol-1-yl)phenyl]urea

HRID 722226Notes

Reaction equation

HRID 722226 reaction equation
[Cl:1][C:2]1[CH:12]=[C:11]([F:13])[CH:10]=[CH:9][C:3]=1[C:4]([N:6]=[C:7]=[O:8])=[O:5].[NH2:14][C:15]1[CH:20]=[CH:19][C:18]([N:21]2[C:25](=[O:26])[CH:24]=[C:23]([CH3:27])[NH:22]2)=[CH:17][C:16]=1[CH3:28]>C(#N)C>[Cl:1][C:2]1[CH:12]=[C:11]([F:13])[CH:10]=[CH:9][C:3]=1[C:4]([NH:6][C:7]([NH:14][C:15]1[CH:20]=[CH:19][C:18]([N:21]2[C:25](=[O:26])[CH:24]=[C:23]([CH3:27])[NH:22]2)=[CH:17][C:16]=1[CH3:28])=[O:8])=[O:5]

Participants

4

Reactant 2

HCID 11521269Benzoyl isocyanate, 2-chloro-4-fluoro-HCID 218838762-(4-Amino-3-methylphenyl)-5-methyl-1,2-dihydro-3H-pyrazol-3-one

Product 1

HCID 121487531-(2-Chloro-4-fluorobenzoyl)-3-[2-methyl-4-(3-methyl-5-oxo-2,5-dihydropyrazol-1-yl)phenyl]urea

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent2×

Procedure

The solution of equivalent amounts of 2-chloro-4-fluorobenzoyl isocyanate in acetonitrile was added dropwise to the solution of 71 mg of 2-(4-amino-3-methylphenyl)-5-methyl-1,2-dihydropyrazol-3-one in 6 ml of acetonitrile and the mixture was stirred at room temperature overnight. The solid formed was filtered off with suction and dried under reduced pressure.

Workup

  1. customThe solid formed
  2. filtrationwas filtered off with suction
  3. customdried under reduced pressure

Sources & evidence

ORD record
ord-3bcd18f2b52d4e538d5bd971532d00b7
Source dataset
uspto-grants-2006_11
Patent number
US07138414B2

Reaction notes

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