2-Chloro-4,5-difluorobenzoyl Isocyanate → HCID 21883897, compound

HRID 722231Notes

Reaction equation

HRID 722231 reaction equation
[Cl:1][C:2]1[CH:12]=[C:11]([F:13])[C:10]([F:14])=[CH:9][C:3]=1[C:4]([N:6]=[C:7]=[O:8])=[O:5].[Cl:15][C:16]1[CH:21]=[CH:20][C:19]([C:22]2[N:23]=[N:24][C:25]([CH3:29])=[C:26]([CH3:28])[N:27]=2)=[CH:18][C:17]=1[NH2:30]>C(#N)C>[Cl:1][C:2]1[CH:12]=[C:11]([F:13])[C:10]([F:14])=[CH:9][C:3]=1[C:4]([NH:6][C:7]([NH:30][C:17]1[CH:18]=[C:19]([C:22]2[N:23]=[N:24][C:25]([CH3:29])=[C:26]([CH3:28])[N:27]=2)[CH:20]=[CH:21][C:16]=1[Cl:15])=[O:8])=[O:5]

Participants

4

Reactant 2

HCID 115575832-Chloro-4,5-difluorobenzoyl IsocyanateHCID 218838862-Chloro-5-(5,6-dimethyl-1,2,4-triazin-3-yl)aniline

Product 1

HCID 21883897HCID 21883897, compound

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Procedure

The solution of equivalent amounts of 2-chloro-4,5-difluorobenzoyl isocyanate was added dropwise to the solution of 75 mg of 2-chloro-5-(5,6-dimethyl-[1,2,4]triazin-3-yl)phenylamine in 8 ml of acetonitrile and the mixture was stirred at room temperature for 30 minutes. The solid was filtered off with suction and dried under reduced pressure.

Workup

  1. filtrationThe solid was filtered off with suction
  2. customdried under reduced pressure

Sources & evidence

ORD record
ord-71bb3e5cc665478c8a2988a500e20319
Source dataset
uspto-grants-2006_11
Patent number
US07138414B2

Reaction notes

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