HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 722235Generated: October 30, 2026
Hydrochloric Acid → 1-(4-Fluoro-2-nitrophenyl)piperidine-4-carboxylic acid
https://huagongshe.com/reaction/722235
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | 4-Piperidinecarboxylic acid | HCID 3773 | — |
| Reactant | N-methyl-2-pyrrolidone | HCID 13387 | — |
| Reactant | 2,5-Difluoronitrobenzene | HCID 67767 | — |
| Solvent | Water | HCID 962 | — |
| Product | 1-(4-Fluoro-2-nitrophenyl)piperidine-4-carboxylic acid | HCID 21883881 | — |
Reaction Steps
The mixture consisting of 1.62 g of 2,5-difluoronitrobenzene, 1.9 g of piperidine-4-carboxylic acid and 10 ml of NMP was heated with stirring to 80° C. for 2 hours. After it had been allowed to cool, 30 ml of water were added and the mixture was made weakly acidic using 2N hydrochloric acid and stirred at RT. The precipitated solid was filtered off with suction and dried under reduced pressure.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US07138414B2 |
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| Source dataset | uspto-grants-2006_11 |
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| ORD ID | ord-c1bef3095cf04279991447ded646426f |
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| Source note | uspto-grants-2006_11 |
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