Water → 4-Piperidinecarboxylic acid, 1-(2-amino-4-fluorophenyl)-, hydrochloride (1:1)

Participants

Reaction Steps

The solution of 804 mg of 1-(4-fluoro-2-nitrophenyl)piperidine-4-carboxylic acid in 40 ml of ethyl acetate was admixed with 3.8 g of tin(II) chloride and stirred at RT for 2 hours. 50 ml of water were then added and the mixture was filtered through a clarifying layer. The ethyl acetate phase was removed, dried over sodium sulfate and concentrated by rotary evaporator, leaving a semisolid residue which was subjected directly to further reaction.

Provenance & Evidence