HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Chloro-4,5-difluorobenzoyl Isocyanate → AVE2865
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Chloro-4,5-difluorobenzoyl Isocyanate | HCID 11557583 | — |
| Reactant | 4-Piperidinecarboxylic acid, 1-(2-amino-4-fluorophenyl)-, hydrochloride (1:1) | HCID 69437037 | — |
| Solvent | Acetonitrile | HCID 6342 | — |
| Product | AVE2865 | HCID 12148754 | — |
Reaction Steps
The equimolar solution of 2-chloro-4,5-difluorobenzoyl isocyanate in acetonitrile was added dropwise to the solution of 53 mg of 1-(2-amino-4-fluorophenyl)piperidine-4-carboxylic acid hydrochloride in 3 ml of acetonitrile with stirring. The mixture was stirred at RT for 6 h and the precipitate was filtered off with suction and dried at RT under reduced pressure.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07138414B2 |
| Source dataset | uspto-grants-2006_11 |
| ORD ID | ord-7b9361d0f10545ea86094c39eda1ab86 |
| Source note | uspto-grants-2006_11 |