HCID 2758791, compound → HCID 10175289, compound

HRID 722254Notes

Reaction equation

HRID 722254 reaction equation
[NH2:1][CH:2]([C:9]1[CH:14]=[C:13]([Cl:15])[CH:12]=[C:11]([Cl:16])[CH:10]=1)[CH2:3][C:4]([O:6]CC)=[O:5].[CH2:17]([O:24][CH2:25][CH:26]([NH:30][C:31]([O:33][CH2:34][CH2:35][CH2:36][NH:37][C:38]1[CH:43]=[CH:42][CH:41]=[CH:40][N:39]=1)=[O:32])[C:27](O)=[O:28])[C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1>>[CH2:17]([O:24][CH2:25][CH:26]([NH:30][C:31]([O:33][CH2:34][CH2:35][CH2:36][NH:37][C:38]1[CH:43]=[CH:42][CH:41]=[CH:40][N:39]=1)=[O:32])[C:27]([NH:1][CH:2]([C:9]1[CH:10]=[C:11]([Cl:16])[CH:12]=[C:13]([Cl:15])[CH:14]=1)[CH2:3][C:4]([OH:6])=[O:5])=[O:28])[C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1

Participants

3

Reactant 2

HCID 2758791HCID 2758791, compoundHCID 21884082HCID 21884082, compound

Product 1

HCID 10175289HCID 10175289, compound

Procedure

Analogously to Example 2, ethyl 3-amino-3-(3,5-dichlorophenyl)propionate is reacted with 3-benzyloxy-2-[3-(pyridin-2-ylamino)propoxycarbonylamino]-propionic acid and purified by preparative HPLC, giving 3-{3-benzyloxy-2-[3-(pyridin-2-ylamino)propoxycarbonylamino]propanoylamino}-3-(3,5-dichlorophenyl)propionic acid, RT 1.598 min, FAB-MS (M+H)+ 590.

Workup

  1. custompurified by preparative HPLC

Sources & evidence

ORD record
ord-5913c67a4fab42738ad9d5c1347404db
Source dataset
uspto-grants-2006_11
Patent number
US07138417B2

Reaction notes

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