HCID 2758791, compound → HCID 21884080, compound

HRID 722255Notes

Reaction equation

HRID 722255 reaction equation
[NH2:1][CH:2]([C:9]1[CH:14]=[C:13]([Cl:15])[CH:12]=[C:11]([Cl:16])[CH:10]=1)[CH2:3][C:4]([O:6][CH2:7][CH3:8])=[O:5].[CH2:17]([O:24][CH2:25][CH:26]([NH:30][C:31]([O:33][CH2:34][CH2:35][NH:36][C:37]1[CH:42]=[CH:41][CH:40]=[C:39]([CH3:43])[N:38]=1)=[O:32])[C:27](O)=[O:28])[C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1>>[CH2:17]([O:24][CH2:25][CH:26]([NH:30][C:31]([O:33][CH2:34][CH2:35][NH:36][C:37]1[CH:42]=[CH:41][CH:40]=[C:39]([CH3:43])[N:38]=1)=[O:32])[C:27]([NH:1][CH:2]([C:9]1[CH:10]=[C:11]([Cl:16])[CH:12]=[C:13]([Cl:15])[CH:14]=1)[CH2:3][C:4]([O:6][CH2:7][CH3:8])=[O:5])=[O:28])[C:18]1[CH:19]=[CH:20][CH:21]=[CH:22][CH:23]=1

Participants

3

Reactant 2

HCID 2758791HCID 2758791, compoundHCID 21884083HCID 21884083, compound

Product 1

HCID 21884080HCID 21884080, compound

Procedure

Analogously to Example 2, ethyl 3-amino-3-(3,5-dichlorophenyl)propionate is reacted with 3-benzyloxy-2-[2-(6-methylpyridin-2-ylamino)ethoxycarbonylamino]propionic acid and purified by chromatography, giving ethyl 3-{3-benzyloxy-2-[2-(6-methylpyridin-2-ylamino)ethoxycarbonylamino]-propanoylamino}-3-(3,5-dichlorophenyl)propionate, RT 1.765 min, FAB-MS (M+H)+ 618.

Workup

  1. custompurified by chromatography

Sources & evidence

ORD record
ord-14a8463e1a384417aacba2a2669849e6
Source dataset
uspto-grants-2006_11
Patent number
US07138417B2

Reaction notes

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