1-Ethyl-3-(3'-dimethylaminopropyl)carbodiimide → HCID 24886043, compound

Participants

Reaction Steps

5-Chloro-1H-indol-2-carboxylic acid (196 mg, 1.0 mmol), N-[(1R,2R)-2-amino-2,3-dihydro-1H-inden-1-yl]methanesulfonamide (Method 2; 226 mg, 1.0 mmol), DIPEA (0.17 ml, 1.0 mmol), and HOBT (130 mg, 1.0 mmol) was stirred in DCM (10 ml) for one minute. EDCI (240 mg, 1.25 mmol) was added and the mixture stirred at room temperature for 20 hours. The mixture was diluted with EtOAc, washed with water (2×25 ml), dried over magnesium sulphate and evaporated to give the title compound (320 mg, 79%) as a foam.

Provenance & Evidence