Triethylamine → HCID 24887022, compound

Participants

Reaction Steps

N-[(1R,2R)-1-Amino-2,3-dihydro-1H-inden-2-yl]-5-chloro-1H-indole-2-carboxamide trifluoroacetic acid salt (Method 5, 2.2 g, 5.0 mmol) and Et3N (2.1 mL, 15.0 mmol) dissolved in dry THF (30 mL) at 5° C., chloromethyl sulphonyl chloride (820 mg, 5.5 mmol) in dry THF (5 mL) was added and the reaction allowed to warm to ambient temperature for 2 hours. The volatiles were removed by evaporation under reduced pressure and the residue dissolved in EtOAc (75 mL), washed with water (2×25 mL), brine (25 mL) and dried (MgSO4). Removal of the volatiles under reduced pressure gave the title compound (2.16 g, 98%) as a buff powder.

Provenance & Evidence