Ethyl Acetate → HCID 21883935, compound

Participants

Reaction Steps

N-[1-Amino-2,3-dihydro-1H-inden-2-yl]-5-chloro-1H-indole-2-carboxamide trifluoroacetic acid salt (Method 4, 220 mg, 0.5 mmol), DIPEA (260 μL, 1.5 mmol) and bromoacetonitrile (37 μL, 0.55 mmol) in acetonitrile (5 mL) were heated in a microwave to 180° C. for 1 min. EtOAc (30 mL) was added and the mixture washed with water,(2×10 mL), brine (10 mL), dried (MgSO4) and evaporated. The residue was purified by column chromatography (EtOAc:Hexane 1:1) to afford the title compound (110 mg, 60%) as a white foam.

Provenance & Evidence