2-Thiophenecarboxaldehyde → HCID 69585891, compound

Participants

Reaction Steps

2-Thiophenecarboxaldehyde (80 μL, 0.8 mmol) and potassium acetate (90 mg, 0.9 mmol) were added to a solution of N-{(1S,2S)-1-amino-2,3-dihydro-1H-inden-2-yl}-5-chloro-1H-indole-2-carboxamide (Method 5b, 400 mg, 0.9 mmol) in MeOH (10 mL). The reaction was stirred at ambient temperature for approximately 5 mins then macroporous triethylammonium methyl polystyrene cyanoborohydride (540 mg, 0.9 mmol) was added and the reaction stirred at ambient temperature for a further 3 h. The reaction was then filtered and the volatiles were removed by evaporation under reduced pressure to afford N-{(1S,2S)-1-[(2-thienylmethyl)amino]-2,3-dihydro-1H-inden-2-yl}-5-chloro-1H-indole-2-carboxamide which was used crude in the next stage.

Provenance & Evidence