Methanol → HCID 24886519, compound

Participants

Reaction Steps

Potassium carbonate (20 mg) and MeOH (1 mL) were added to a solution of N-{(1R,2R)-1-[N-(2-acetoxyacetyl)-N-(carboxymethyl)amino]-2,3-dihydro-1H-inden-2-yl}-5-chloroindole-2-carboxamide (Example 35, 184 mg, 0.38 mmol) in THF (5 mL) and the reaction was stirred at ambient temperature for 24 h. The volatiles were removed by evaporation under reduced pressure, the residue dissolved in water and acidified to pH 2.0 and then extracted into EtOAc (3×10 mL). The volatiles were removed by evaporation under reduced pressure and the residue purified by column chromatography (EtOAc:isohexane 1:4) to afford the title compound (50 mg, 31%) as a white solid.

Provenance & Evidence