4-(4-Methyl-1,4-diazepan-1-yl)aniline → 6-Isobutyryl-3-[4-(4-methyl[1,4]diazepan-1-yl)phenyl]-3H-thieno[3,2-d]pyrimidin-4-one

HRID 72228Notes

Reaction equation

HRID 72228 reaction equation
CO[C:3]([C:5]1[S:6][C:7]([C:15](=[O:19])[CH:16]([CH3:18])[CH3:17])=[CH:8][C:9]=1[N:10]=[CH:11][N:12]([CH3:14])C)=[O:4].[CH3:20][N:21]1[CH2:27][CH2:26][CH2:25][N:24]([C:28]2[CH:33]=[CH:32]C(N)=[CH:30][CH:29]=2)[CH2:23][CH2:22]1>>[C:15]([C:7]1[S:6][C:5]2[C:3](=[O:4])[N:12]([C:14]3[CH:32]=[CH:33][C:28]([N:24]4[CH2:25][CH2:26][CH2:27][N:21]([CH3:20])[CH2:22][CH2:23]4)=[CH:29][CH:30]=3)[CH:11]=[N:10][C:9]=2[CH:8]=1)(=[O:19])[CH:16]([CH3:17])[CH3:18]

Participants

3

Reactant 2

HCID 130079514-(4-Methyl-1,4-diazepan-1-yl)anilineHCID 689771743-(Dimethylaminomethyleneamino)-5-isobutyrylthiophene-2-carboxylic acid methyl ester

Product 1

HCID 248597066-Isobutyryl-3-[4-(4-methyl[1,4]diazepan-1-yl)phenyl]-3H-thieno[3,2-d]pyrimidin-4-one

Procedure

3-(Dimethylaminomethyleneamino)-5-isobutyrylthiophene-2-carboxylic acid methyl ester and 4-(4-methyl[1,4]diazepan-1-yl)phenylamine were reacted by method A1. The product with the molecular weight of 410.54 (C22H26N4O2S) was obtained in this way; MS (ESI): 411 (M+H+).

Workup

  1. customThe product with the molecular weight of 410.54 (C22H26N4O2S) was obtained in this way

Sources & evidence

ORD record
ord-83190fffe4fd420d93480431c79ae603
Source dataset
uspto-grants-2014_09
Patent number
US08828991B2

Reaction notes

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