1-Chloroethyl chloroformate → HCID 131726064, compound

Participants

Reaction Steps

To a solution of trans-tert-butyl-3-(1-benzyl-4-(ethoxycarbonyl)pyrrolidin-3-yl)-1H-indole-1-carboxylate (8.57 mmol) in dichloromethane (16 mL) was added 1-chloroethyl chloroformate (1.11 mL) slowly at 0° C. After addition, the mixture was warmed up to room temperature and stirred for 1 hr then concentrated under vacuum. Ethyl alcohol was added and the mixture was stirred at room temperature for 1 hr. The mixture was concentrated under vacuum to give the crude product as a white solid which was used for next step without further purification.

Provenance & Evidence