Hydrochloric Acid → HCID 21884201, compound

Participants

Reaction Conditions

Reaction Steps

To a suspension of the above benzamide (169 mg, 0.325 mmol) in dioxane (15 mL) was added 0.01 N HCl (15 mL) and the suspension warmed to 95° C. After 3 hours, the reaction appeared complete by TLC and the solution cooled to room temperature. The solid that crashed out of solution as the reaction cooled was collected by filtration, washed with water, and dried to afford 4-cyano-N-[5-hydroxymethyl-1-(2-methoxy-ethyl)-1H-benzimidazol-2-yl]-benzamide as a yellow solid (109 mg, 92%).

Provenance & Evidence