HCID 21884201, compound → HCID 21884197, compound

Participants

Reaction Steps

To a solution of 4-cyano-N-[5-hydroxymethyl-1-(2-methoxy-ethyl)-1H-benzimidazol-2-yl]-benzamide (15.4 mg, 0.042 mmol) in acetone (2 mL) was added manganese (IV) oxide (43 mg, 0.42 mmol). After stirring overnight, the black suspension was filtered thru diatomaceous earth and the filtrate concentrated. The filtrate was dissolved in acetone and run through a 2 g SepPak silica gel cartridge to afford 4-cyano-N-[5-formyl-1-(2-methoxy-ethyl)-1H-benzimidazol-2-yl]-benzamide as a white solid (13 mg, 84%).

Provenance & Evidence