4-(Chloromethyl)pyridinium chloride → HCID 58742380, compound

HRID 722425Notes

Reaction equation

HRID 722425 reaction equation
[CH2:1]([C@:3]12[C:16]3[C:11](=[CH:12][C:13]([OH:17])=[CH:14][CH:15]=3)[CH2:10][CH2:9][C@@H:8]1[CH2:7][C@:6]([C:19]1[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=1)([OH:18])[C@@H:5]([OH:25])[CH2:4]2)[CH3:2].Cl.[N:27]1[CH:32]=[CH:31][C:30]([CH2:33]Cl)=[CH:29][CH:28]=1>>[CH2:1]([C@:3]12[C:16]3[C:11](=[CH:12][C:13]([O:17][CH2:33][C:30]4[CH:31]=[CH:32][N:27]=[CH:28][CH:29]=4)=[CH:14][CH:15]=3)[CH2:10][CH2:9][C@@H:8]1[CH2:7][C@:6]([C:19]1[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=1)([OH:18])[C@@H:5]([OH:25])[CH2:4]2)[CH3:2]

Participants

3

Reactant 2

HCID 745704-(Chloromethyl)pyridinium chlorideHCID 25258386HCID 25258386, compound

Product 1

HCID 58742380HCID 58742380, compound

Procedure

The title compound was prepared starting from the title product of Example 16 and 4-picolyl chloride hydrochloride using a procedure analogous to that outlined for Example 2. Product was isolated by flash chromatography eluting with 25% ethyl acetate in methylene chloride. Mass spectrum: m/e 430 (M+1).

Workup

  1. customProduct was isolated by flash chromatography
  2. washeluting with 25% ethyl acetate in methylene chloride

Sources & evidence

ORD record
ord-cebf2af60fa34e928f136791aa4010c7
Source dataset
uspto-grants-2006_11
Patent number
US07138406B2

Reaction notes

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