Chloroacetonitrile → HCID 68834040, compound

HRID 722437Notes

Reaction equation

[CH2:1]([C@:3]12[C:16]3[C:11](=[CH:12][C:13]([OH:17])=[CH:14][CH:15]=3)[CH2:10][CH2:9][C@@H:8]1[CH2:7][C@:6]([C:19]1[CH:24]=[CH:23][CH:22]=[CH:21][N:20]=1)([OH:18])[C@:5]([CH3:26])([OH:25])[CH2:4]2)[CH3:2].Cl[CH2:28][C:29]#[N:30]>>[CH2:1]([C@@:3]12[CH2:4][C@:5]([OH:25])([CH3:26])[C@:6]([OH:18])([C:19]3[CH:24]=[CH:23][CH:22]=[CH:21][N:20]=3)[CH2:7][C@H:8]1[CH2:9][CH2:10][C:11]1[CH:12]=[C:13]([O:17][CH2:28][C:29]#[N:30])[CH:14]=[CH:15][C:16]2=1)[CH3:2]

Participants

Reactant 2

HCID 7856Chloroacetonitrile

HCID 10450738HCID 10450738, compound

Product 1

HCID 68834040HCID 68834040, compound

Procedure

The title compound was prepared from the compound of Example 102 according to the procedure of Example 57, running the reaction at room temperature overnight and using chloroacetonitrile as the alkylating agent. Mass spectrum (m/e) 393 (M++1).

Workup

customthe reaction at room temperature overnight

Sources & evidence

ORD record: ord-361d39d3c83d490ebf79adab06ac7525
Source dataset: uspto-grants-2006_11
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07138406B2

Reaction notes

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