3-Amino-4-methoxybenzoic acid → HCID 10106350, compound

HRID 722480Notes

Reaction equation

HRID 722480 reaction equation
[NH2:1][C:2]1[CH:7]=[CH:6][C:5]([CH3:8])=[CH:4][C:3]=1[OH:9].[CH3:10][O:11][C:12]1[CH:20]=[CH:19][C:15]([C:16](O)=O)=[CH:14][C:13]=1[NH2:21]>>[NH2:21][C:13]1[CH:14]=[C:15]([C:16]2[O:9][C:3]3[CH:4]=[C:5]([CH3:8])[CH:6]=[CH:7][C:2]=3[N:1]=2)[CH:19]=[CH:20][C:12]=1[O:11][CH3:10]

Participants

3

Reactant 2

HCID 178233-Amino-4-methoxybenzoic acidHCID 760822-Amino-5-methylphenol

Product 1

HCID 10106350HCID 10106350, compound

Procedure

Prepared by the method of Example 1a), from 2-amino-5-methylphenol (368 mg, 2.9 mmol) and 4-methoxy-3-aminobenzoic acid (500 mg, 2.9 mmol) the subtitle compound was obtained, 75 mg (10%). 1H NMR (CDCl3) δ 7.69–7.58(m, 4H), 7.35(bs, 1H), 6.92(d, J=7.9 Hz), 3.85(s, 3H), 2.51(s, 3H). MS 255 m/z (M+H)+.

Sources & evidence

ORD record
ord-601bf126fd174a30909a9a650b4aeb93
Source dataset
uspto-grants-2006_11
Patent number
US07138425B2

Reaction notes

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