2-Aminophenol → HCID 735944, compound

HRID 722486Notes

Reaction equation

HRID 722486 reaction equation
[NH2:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1O.[CH3:9][O:10][C:11]1[CH:19]=[CH:18][C:14]([C:15]([OH:17])=O)=[CH:13][C:12]=1[NH2:20]>>[NH2:20][C:12]1[CH:13]=[C:14]([C:15]2[O:17][C:3]3[CH:4]=[CH:5][CH:6]=[CH:7][C:2]=3[N:1]=2)[CH:18]=[CH:19][C:11]=1[O:10][CH3:9]

Participants

3

Reactant 2

HCID 58012-AminophenolHCID 178233-Amino-4-methoxybenzoic acid

Product 1

HCID 735944HCID 735944, compound

Procedure

Prepared by the method of Example 1a), from 2-aminophenol (326 mg, 2.9 mmol) and 4-methoxy-3-aminobenzoic acid (500 mg, 2.9 mmol) the subtitle compound was obtained, 97 mg (13%). 1H NMR (CDCl3) δ 7.66–7.45(m, 4H), 7.24(m, 2H), 6.82(d, J=8.3 Hz, 1H), 3.86(s, 3H). MS 241 m/z (M+H)+.

Sources & evidence

ORD record
ord-0eb1278298a548ac98bbd014176653bb
Source dataset
uspto-grants-2006_11
Patent number
US07138425B2

Reaction notes

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