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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 722494Generated: October 30, 2026

HCID 21884400, compound → 2-(3-Amino-4-methoxyphenyl)-5-(benzofuran-2-yl)benzoxazole

https://huagongshe.com/reaction/722494

Reaction equation

Participants

RoleNameHCIDCharge
ReactantHCID 21884400HCID 21884400—
CatalystPalladiumHCID 23938—
Solvent1,4-DioxaneHCID 31275—
Product2-(3-Amino-4-methoxyphenyl)-5-(benzofuran-2-yl)benzoxazoleHCID 2188459186.3%

Reaction Steps

A suspension of 2-(3-nitro-4-methoxyphenyl)-5-(benzofuran-2-yl)benzoxazole (50 mg, 0.13 mmol) in dioxane (10 ml) was placed under an atmosphere of argon. Palladium on carbon (10%) (10 mg) was added and the reaction purged with hydrogen and stirred at room temperature for 36 h. The reaction was filtered through a bed of celite and the filtrate concentrated to give the subtitle compound (40 mg, 86%). MS m/z 357.1 (M+H)+.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07138425B2
Source datasetuspto-grants-2006_11
ORD IDord-58308e7288d84d54baaa8b63198f2575
Source noteuspto-grants-2006_11