4-(Trifluoromethyl)phenylboronic acid → 2-(3-Nitro-4-methoxyphenyl)-5-(4-trifluoromethylphenyl)benzoxazole

Participants

Reaction Steps

Prepared by the method of Example 15d), from 2-(3-nitro-4-methoxyphenyl)-5-bromobenzoxazole (200 mg, 0.57 mmol) and 4-trifluoromethylphenylboronic acid (161 mg, 0.85 mmol) the subtitle compound was obtained (204 mg, 58%). 1H NMR (DMSO) δ 8.64(d, 1H), 8.46(dd, 1H), 8.16(d, 1H), 7.97(d, 2H), 7.92(d, 1H), 7.85–7.78(m, 3H), 7.63(d, 1H), 4.05(s, 3H).

Provenance & Evidence