3-Fluorophenylboronic acid → HCID 21884336, compound

HRID 722510Notes

Reaction equation

HRID 722510 reaction equation
[N+:1]([C:4]1[CH:5]=[C:6]([C:12]2[O:13][C:14]3[CH:20]=[CH:19][C:18](Br)=[CH:17][C:15]=3[N:16]=2)[CH:7]=[CH:8][C:9]=1[O:10][CH3:11])([O-:3])=[O:2].[F:22][C:23]1[CH:24]=[C:25](B(O)O)[CH:26]=[CH:27][CH:28]=1>>[N+:1]([C:4]1[CH:5]=[C:6]([C:12]2[O:13][C:14]3[CH:20]=[CH:19][C:18]([C:27]4[CH:26]=[CH:25][CH:24]=[C:23]([F:22])[CH:28]=4)=[CH:17][C:15]=3[N:16]=2)[CH:7]=[CH:8][C:9]=1[O:10][CH3:11])([O-:3])=[O:2]

Participants

3

Reactant 2

HCID 27339863-Fluorophenylboronic acidHCID 218843422-(3-Nitro-4-methoxyphenyl)-5-bromobenzoxazole

Product 1

HCID 21884336HCID 21884336, compound

Procedure

Prepared by the method of Example 15d), from 2-(3-nitro-4-methoxyphenyl)-5-bromobenzoxazole (200 mg, 0.57 mmol) and 3-fluorophenylboronic acid (120 mg, 0.86 mmol) the subtitle compound was obtained, (103 mg, 49%). 1H NMR (DMSO) δ 8.59(d, 1H), 8.40(dd, 1H), 8.08(d, 1H), 7.82(d, 1H), 7.72(dd, 1H), 7.52(m, 4H), 7.17(dt, 1H), 4.02(s, 3H).

Sources & evidence

ORD record
ord-0ff1e68e5f0a47a4a002b58d32180a22
Source dataset
uspto-grants-2006_11
Patent number
US07138425B2

Reaction notes

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