(3,5-Difluorophenyl)boronic acid → 2-(3-Nitro-4-methoxyphenyl)-5-(3,5-difluorophenyl)benzoxazole

Participants

Reaction Steps

Prepared by the method of Example 15d), from 2-(3-nitro-4-methoxyphenyl)-5-bromobenzoxazole (200 mg, 0.57 mmol) and 3,5-difluorophenylboronic acid (136 mg, 0.86 mmol) the subtitle compound was obtained, (120 mg, 64%). 1H NMR (DMSO) δ 8.70(d, 1H), 8.52(dd, 1H), 8.26(d, 1H), 7.96(d, 1H), 7.88(dd, 1H), 7.69(d, 1H), 7.61(dd, 2H), 7.33(tt, 1H), 4.12(s, 3H). MS 383 m/z (M+H)+.

Provenance & Evidence