HCID 21884582, compound → HCID 21884298, compound

Participants

Reaction Steps

Prepared by the method of Example 15e), from palladium (10 mol %) on carbon (10 mg, 0.1 mmol) and 2-(3-nitro-4-ethoxyphenyl)-5-phenylbenzoxazole (100 mg, 0.3 mmol) in dioxane (1 ml) which gave the crude subtitle compound (51 mg, 56%) as a white solid which was sufficiently pure (by TLC and 1H NMR spectroscopy) to be used in the next step, RF(2:1 Petrol-EtOAc) 0.50; 1H NMR (CDCl3) δ 7.92(1H, d, J=1.0, Ar), 7.68–7.60(4H, m, Ar), 7.57–7.51(2H, m, Ar), 7.47(2H, brt, J=7.0 Hz, Ar), 7.36(1H, tt, J=1.0, 6.5 Hz, Ar), 6.89(1H, d, J=8.5 Hz, Ar), 4.16(2H, q, J=7.0 Hz, CH2), 3.98(2H, brs, NH2), 1.49(1H, t, J=2.5 Hz, CH3).

Provenance & Evidence