HuagongsheHuagongshe Chemistry Print Report · For research reference only
p-Toluenesulfonic acid monohydrate → 2-(2-Fluoro-5-nitrophenyl)-5-phenylbenzoxazole
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | p-Toluenesulfonic acid monohydrate | HCID 521998 | — |
| Reactant | N-(2-hydroxy-5-bromophenyl)-2-fluoro-5-nitrobenzamide | HCID 21884381 | — |
| Product | 2-(2-Fluoro-5-nitrophenyl)-5-phenylbenzoxazole | HCID 21884334 | — |
Reaction Steps
Prepared by the method of Example 15c), from N-(2-hydroxy-5-bromophenyl)-2-fluoro-5-nitrobenzamide (11.0 g, 0.03 mol) and p-toluenesulfonic acid monohydrate (11.88 g, 0.06 mol) the subtitle compound was obtained (6 g, 58%). 1H NMR (DMSO) δ 8.98(dd, 1H), 8.54(m, 1H), 8.19(d, 1H), 7.97(d, 1H), 7.81(m, 4H), 7.52(t, 2H), 7.42(d, 1H).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07138425B2 |
| Source dataset | uspto-grants-2006_11 |
| ORD ID | ord-326d3265b42b4eb1917917ef2323126a |
| Source note | uspto-grants-2006_11 |