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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 722523Generated: October 30, 2026

Sodium ethoxide → 2-(5-Nitro-2-ethoxyphenyl)-5-phenylbenzoxazole

https://huagongshe.com/reaction/722523

Reaction equation

Participants

RoleNameHCIDCharge
ReactantSodium ethoxideHCID 2723922—
Reactant2-(2-Fluoro-5-nitrophenyl)-5-phenylbenzoxazoleHCID 21884334—
Product2-(5-Nitro-2-ethoxyphenyl)-5-phenylbenzoxazoleHCID 21884572—

Reaction Steps

Prepared by the method of Example 40a), from 2-(5-nitro-2-fluorophenyl)-5-phenylbenzoxazole (200 mg, 0.60 mmol) and sodium ethoxide (41 mg, 0.61 mmol) the subtitle compound was obtained (197 mg, 91%). 1H NMR (DMSO) δ 8.92(d, 1H), 8.51(dd, 1H), 8.18(s, 1H), 7.95(d, 1H), 7.83(d, 2H), 7.56(t, 3H), 7.47(t, 3H), 4.50(q, 2H), 1.57(t, 3H).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07138425B2
Source datasetuspto-grants-2006_11
ORD IDord-ef2930e60d9c4601802f454f0e231626
Source noteuspto-grants-2006_11