HuagongsheHuagongshe Chemistry Print Report · For research reference only
p-Toluenesulfonic acid monohydrate → 2-(2-Fluoro-5-nitrophenyl)-5-bromobenzoxazole
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | p-Toluenesulfonic acid monohydrate | HCID 521998 | — |
| Reactant | N-(2-hydroxy-5-bromophenyl)-2-fluoro-5-nitrobenzamide | HCID 21884381 | — |
| Product | 2-(2-Fluoro-5-nitrophenyl)-5-bromobenzoxazole | HCID 21884439 | — |
Reaction Steps
Prepared by the method of Example 15b), from N-(2-hydroxy-5-bromophenyl)-2-fluoro-5-nitrobenzamide (1.42 g, 4.0 mmol) and p-toluenesulfonic acid monohydrate (1.67 g, 8.8 mmol) the subtitle compound was obtained (654 mg, 48%). MS 339.0 m/z (M+H)+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07138425B2 |
| Source dataset | uspto-grants-2006_11 |
| ORD ID | ord-c3d534ec6a7b485bb3a24f15d13f18aa |
| Source note | uspto-grants-2006_11 |